Harnessing Science to Combat Canine Cancer
Exploring the mechanisms by which repurposed medications may aid in treating cancer in dogs
Over the last two decades, researchers have begun exploring how certain off-label medications and supplements might impact cancer cell behavior — not just in humans, but in dogs too. The Samson Plan is built around this emerging evidence. Below, we summarize the most promising findings.
Important Note
Mechanisms of Action
The core medications in the Samson Plan work through several mechanisms to target cancer cells while generally sparing healthy cells. Expand each section to learn more about how these medications work.
Fenbendazole interferes with cancer cell division by destabilizing microtubules, which are essential for cell division. This disruption leads to cell cycle arrest and ultimately cell death, particularly in rapidly dividing cancer cells.
Fenbendazole impairs glucose uptake in cancer cells, disrupting their energy metabolism. Cancer cells rely heavily on glucose for energy (the Warburg effect), making them particularly vulnerable to this mechanism.
Ivermectin may stimulate anti-tumor immune responses, enhancing the body's ability to recognize and fight cancer cells. This immune-enhancing effect can complement other anti-cancer mechanisms.
Both drugs can induce oxidative stress in mitochondria, promoting apoptosis (programmed cell death) in cancer cells. Cancer cells are often more sensitive to this stress than normal cells.
Fenbendazole Metabolism
Fenbendazole undergoes metabolism in the liver through various pathways. Understanding these transformations helps explain its bioavailability and effectiveness.
Fenbendazole (HOE 881) metabolism pathways showing transformation to active metabolites
Implications for Your Dog
While not a guaranteed cure, the Samson Plan offers a promising adjunctive approach to traditional cancer treatments. Many pet owners have reported improved quality of life and extended survival times in their dogs.
The scientific evidence suggests that these repurposed medications may help slow cancer progression through multiple mechanisms, potentially giving your dog more quality time and comfort during their cancer journey.
Always consult with your veterinarian before initiating any new treatment regimen. The Samson Plan should be considered as a complementary approach alongside professional veterinary care.